Cancer is an astronomically diverse, unpredictable evolutionary process. Cancer cells constantly evolve in patients to resist anticancer therapies. Overcoming drug resistance has become the primary challenge in cancer research.
Consistent cures will likely require multiple concurrent or sequential therapies, each of which attacks the cancer cells in an independent way. “Independent” means that if a cancer cell evolves drug resistance to one of the therapies, that resistance would not extend to the other therapies. If a sufficient number of such therapies are administered together or in sequence, the likelihood that the cancer cells could evolve resistance to all of the therapies would be vanishingly small.
